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t(15;17) Fusion Transcripts

Acute promyelocytic leukemia (APL) is a distinctive subtype of acute myelogenous leukemia characterized by a translocation involving the promyelocytic leukemia (PML) gene from chromosome 15 and the retinoic acid receptor (RAR) alpha gene from chromosome 17.

Estimated GFR: Implications for Drug Dosing

Recommendations for dosing of critical drugs which are eliminated by the kidneys are often based on estimated GFR. Which of the five commonly used algorithms provides the best result?

Molecular Diagnosis of Intellectual Disability

Several hundred genes have been associated with intellectual disabilities, making molecular diagnostics challenging. Could targeted high-throughput sequencing shed some light?

Evaluation of an Advanced Nurse Practitioner

Emergency departments throughout the Republic of Ireland face the prospect of curtailing their hours or even closing completely from a shortage of junior physicians. Can ANPs fill the gap?

Update on Gout and Hyperuricemia

This article provides a practical review of the current standard of care in gout and chronic hyperuricemia, and discusses new approaches to treatment and management.

Does mHealth Increase Adherence to Medication?

Adherence to medication is a major problem that affects a large number of chronically ill patients. Could remote interventions via mobile phone help increase compliance?