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Health & Medicine Journal & Academic : Health & Medical
t(15;17) Fusion Transcripts
Acute promyelocytic leukemia (APL) is a distinctive subtype of acute myelogenous leukemia characterized by a translocation involving the promyelocytic leukemia (PML) gene from chromosome 15 and the retinoic acid receptor (RAR) alpha gene from chromosome 17.
Scintigraphic Features of Morquio's Syndrome: A Case Report
The authors present the bone scintigraphy findings of a patient with Morquio's syndrome, a rare mucopolysaccharide storage disease.
Genome-Wide Sequencing for Monogenic Diseases in Canada
This position statement by the Canadian College of Medical Geneticists provides recommendations on clinical genome-wide sequencing for genetic diagnosis of monogenic diseases.
Estimated GFR: Implications for Drug Dosing
Recommendations for dosing of critical drugs which are eliminated by the kidneys are often based on estimated GFR. Which of the five commonly used algorithms provides the best result?
EGFR Protein Expression and Gene Amplification in NSCLC
Epidermal growth factor receptor (EGFR) protein expression & gene amplification were evaluated in primary non-small cell lung carcinoma (NSCLC) specimens & correlated with clinicopathologic findings.
Molecular Diagnosis of Intellectual Disability
Several hundred genes have been associated with intellectual disabilities, making molecular diagnostics challenging. Could targeted high-throughput sequencing shed some light?
Preventive Treatment and Anti-malarial Drug Resistance
Is the use of intermittent preventative malaria treatment in vulnerable populations accelerating the spread of drug resistance?
A Practical Guide for Diagnosing Adult ADHD
Attention-deficit/hyperactivity disorder is often considered a childhood disorder, but symptoms can persist into adulthood.
A Sleeping Phantom Leg Awakened Following Hemicolectomy
This patient experienced late-onset phantom pain 42 years following lower leg amputation. Was his recent hemicolectomy and subsequent chemotherapy to blame?
Adjuvant Chemotherapy in Treating Non-Small-Cell Lung Cancer
Some lung cancer patients may find a modest survival benefit in adjuvant chemotherapy, but high financial costs complicate the issue.
Evaluation of an Advanced Nurse Practitioner
Emergency departments throughout the Republic of Ireland face the prospect of curtailing their hours or even closing completely from a shortage of junior physicians. Can ANPs fill the gap?
Update on Gout and Hyperuricemia
This article provides a practical review of the current standard of care in gout and chronic hyperuricemia, and discusses new approaches to treatment and management.
Postconcussive Syndrome Following Sports-Related Concussion
Primary care physicians are often the first to evaluate patients with postconcussion syndrome. This review summarizes both pharmacologic and nonpharmacologic treatment options for PCS in primary care.
Advanced Imaging in the Diagnosis and Management of Gout
Learn more on the application of advanced imaging tools in gout -- and how they can impact the diagnosis and management of this disease.
Serum Free Light Chain Analysis in Plasma Cell Disorders
What is the most effective method for detecting monoclonal free light chains in multiple myeloma and related disorders? This study compared two diagnostic testing strategies.
Effect of the LCZ696 vs Enalapril on Mode of Death in HF
Is LCZ696 superior to enalapril in reducing heart failure deaths?
Unusual Presentation of Cactus Spines in The Flank of an Elderly Man
A patieŮt presented with painless erythematous papules. Histopathology provided the clue to their mysterious origins.
Does mHealth Increase Adherence to Medication?
Adherence to medication is a major problem that affects a large number of chronically ill patients. Could remote interventions via mobile phone help increase compliance?
Pulmonary Disease Caused by Nontuberculous Mycobacteria
The clinicopathologic spectrum of infections due to nontuberculous mycobacteria (NTM) includes cavitary disease, opportunistic infection, and nodular disease associated with bronchiectasis.
Remission of Severe Restless Legs Syndrome After Excision of Foot Neuromas
Could peripheral nerve neuromas be the source of this patient's restless leg syndrome?